Related Experiment Video
Updated: May 23, 2026
Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
Published on: August 12, 2014
Differences in cardiovascular risk factors and clinical outcomes between Western European and Southeast Asian
Margo Klomp1, Peter Damman, Marcel A M Beijk
1Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands.
Objective:
Percutaneous coronary interventions (PCIs) are increasingly being performed worldwide to treat patients with coronary artery disease. However, studies on the influence of ethnicity on clinical outcomes after PCI are scarce. In our current analysis, we evaluate the differences in baseline clinical, angiographic and procedural characteristics, and 12-month clinical outcomes in patients undergoing nonurgent PCI in Western Europe and in Asia.
Methods:
We analyzed all patients enrolled in the worldwide e-HEALING (electronic Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth) registry living in Western Europe and Asia. All patients were treated with at least one endothelial progenitor cell capturing stent. The main study outcome was target vessel failure at the 12-month follow-up, defined as the composite of cardiac death or myocardial infarction and target vessel revascularization.
Results:
A total of 3504 patients, 2873 living in Western Europe and 731 living in Asia, were assessed in the current analysis. Almost all of the baseline clinical and angiographic characteristics differed significantly between both populations. Target vessel failure at the 12-month follow-up occurred in 11.4% of the Western Europe patients and in 5.6% of the Asian patients (P<0.01).
Conclusion:
We conclude that differences exist in the baseline, angiographic, and procedural characteristics between Western European and Asian patients undergoing nonurgent PCI. In addition, the 1-year clinical outcomes differ significantly after PCI between Western European and Asian patients. Our results indicate that reports from studies performed worldwide should include both overall and regional subgroup outcomes.
