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The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
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Updated: May 23, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
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Published on: November 16, 2016

Relationship between maternal and neonatal Staphylococcus aureus colonization.

Natalia Jimenez-Truque1, Sara Tedeschi, Elizabeth J Saye

  • 1Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. natalia.jimenez@vanderbilt.edu

Pediatrics
|April 5, 2012
PubMed
Summary
This summary is machine-generated.

Maternal Staphylococcus aureus colonization significantly increases infant colonization risk. Early postnatal transmission is the primary route for bacteria like MRSA, impacting newborns shortly after birth.

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Published on: August 12, 2020

Area of Science:

  • Microbiology
  • Neonatal Health
  • Infectious Disease Epidemiology

Background:

  • Staphylococcus aureus (S. aureus) colonization is prevalent in pregnant women.
  • Understanding transmission dynamics from mother to infant is crucial for neonatal health.
  • Methicillin-resistant S. aureus (MRSA) poses a significant public health concern.

Purpose of the Study:

  • To investigate the association between maternal S. aureus colonization and infant colonization.
  • To determine the timing and primary mechanisms of infant S. aureus acquisition.
  • To assess the prevalence of MRSA colonization in mother-infant dyads.

Main Methods:

  • Prospective cohort study design.
  • Enrollment of women at 34-37 weeks gestation.
  • Collection of nasal and vaginal swabs from mothers and infants at multiple time points (enrollment, delivery, 2 & 4 months postbirth).
  • Logistic regression analysis to assess colonization associations.

Main Results:

  • Maternal S. aureus colonization at enrollment increased infant colonization odds at birth, discharge, 2, and 4 months.
  • Infant MRSA colonization peaked at 2 months (20.9%).
  • Concurrent MRSA colonization in dyads showed shared isolate types, including USA300.

Conclusions:

  • S. aureus colonization, including MRSA, is highly common in mother-infant pairs.
  • Infants born to colonized mothers have a higher likelihood of colonization.
  • Early postnatal acquisition is the predominant pathway for infant S. aureus colonization.