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Related Concept Videos

Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Peroxisomes and Mitochondria01:30

Peroxisomes and Mitochondria

Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within peroxisomes...
Peroxisomes01:24

Peroxisomes

Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...

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Related Experiment Video

Updated: May 23, 2026

Peroxisome Staining in Mammalian Cells Using Peroxisome-Specific Probes
05:57

Peroxisome Staining in Mammalian Cells Using Peroxisome-Specific Probes

Published on: December 19, 2025

Peroxisome morphology in pathology.

D Ribeiro1, I Castro, H D Fahimi

  • 1Centre for Cell Biology and Deptartment of Biology, University of Aveiro, Aveiro, Portugal.

Histology and Histopathology
|April 5, 2012
PubMed
Summary
This summary is machine-generated.

Peroxisomes dynamically adapt their form and function, crucial for human health. This review explores peroxisome morphology, dynamics, and their roles in various diseases.

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Area of Science:

  • Cell Biology
  • Biomedical Sciences

Background:

  • Peroxisomes are vital organelles adapting to cellular changes.
  • Peroxisome morphology, number, and function are interconnected.
  • Recent discoveries highlight peroxisome dynamics as a key research area.

Purpose of the Study:

  • To review recent findings on peroxisome biology, dynamics, and morphology modulation.
  • To discuss the role of peroxisome dynamics and morphology in cell pathology.
  • To present examples of altered peroxisome morphology in disease.

Main Methods:

  • Literature review of recent findings in peroxisome biology.
  • Analysis of peroxisome morphology and dynamics in mammals.
  • Discussion of disease-associated alterations in peroxisome morphology.

Main Results:

  • Peroxisome morphology is modulated in response to physiological changes.
  • Altered peroxisome morphology is linked to various diseases, including peroxisome biogenesis disorders, cancer, liver cirrhosis, and viral infections.
  • Defects in peroxisomal morphology machinery contribute to disease.

Conclusions:

  • Peroxisome dynamics and morphology are critical for cellular function and human health.
  • Understanding peroxisome morphology alterations provides insights into disease mechanisms.
  • Further research into peroxisome biology is essential for therapeutic advancements.