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Detrusor Underactivity Model in Rats by Conus Medullaris Transection
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Published on: August 28, 2020

High frequency sacral root nerve block allows bladder voiding.

Adam S Boger1, Narendra Bhadra, Kenneth J Gustafson

  • 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.

Neurourology and Urodynamics
|April 5, 2012
PubMed
Summary
This summary is machine-generated.

Kilohertz frequency electrical conduction block of sacral nerves prevents external urethral sphincter activation, enabling bladder voiding after spinal cord injury. This technique may avoid irreversible surgeries and improve patient quality of life.

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Area of Science:

  • Neuroscience
  • Urology
  • Biomedical Engineering

Background:

  • Spinal cord injury often causes dyssynergic external urethral sphincter (EUS) activity, hindering bladder voiding and leading to complications.
  • Current treatments like sphincterotomies or neurotomies to enable voiding carry risks of incontinence and loss of sacral reflexes.

Purpose of the Study:

  • To investigate the efficacy of kilohertz frequency (KF) electrical conduction block of sacral nerve roots in preventing EUS activation and facilitating bladder voiding.

Main Methods:

  • In six cats, S2 sacral nerve roots were stimulated to induce bladder pressure.
  • Dyssynergic EUS activity was simulated by proximal S1 nerve root stimulation.
  • KF waveforms were applied distally to the S1 nerve root to block conduction and prevent EUS pressure.

Main Results:

  • KF waveforms significantly increased bladder voiding from 3% to 59% in single trials.
  • Repeated or prolonged KF application further increased voiding efficiency to 82% of initial bladder volume.

Conclusions:

  • Sacral nerve block using KF stimulation effectively prevents EUS activation, allowing complete bladder voiding.
  • This approach offers a potential alternative to neurotomy, improving patient acceptance of neuroprostheses and enhancing quality of life.