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Updated: May 23, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat
Nur Basak Surmeli1, Michael A Marletta
1QB3 Institute, University of California, Berkeley, CA 94720, USA.
Abstract:
Nitric oxide (NO) signaling mediates many important physiological processes through the receptor soluble guanylate cyclase (sGC). Under disease conditions sGC heme can be oxidized resulting in NO insensitivity. Here, we show that the therapeutic compound cinaciguat (Cin) rescues dysfunctional sGC by direct displacement of the oxidized heme.
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