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Updated: May 23, 2026

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
Published on: April 23, 2016
Retrotransposon insertion targeting: a mechanism for homogenization of centromere sequences on nonhomologous
James A Birchler1, Gernot G Presting
1Division of Biological Sciences, University of Missouri at Columbia, Columbia, Missouri 65211, USA. birchlerj@missouri.edu
Abstract:
The centromeres of most eukaryotic organisms consist of highly repetitive arrays that are similar across nonhomologous chromosomes. These sequences evolve rapidly, thus posing a mystery as to how such arrays can be homogenized. Recent work in species in which centromere-enriched retrotransposons occur indicates that these elements preferentially insert into the centromeric regions. In two different Arabidopsis species, a related element was recognized in which the specificity for such targeting was altered. These observations provide a partial explanation for how homogenization of centromere DNA sequences occurs.
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