Links between metabolic syndrome and cardiovascular autonomic dysfunction
G Garruti1, F Giampetruzzi, M G Vita
1Unit of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantations (D.E.T.O.), University of Bari A. Moro, 70124 Bari, Italy. g.garruti@endo.uniba.it
Experimental Diabetes Research
|April 5, 2012
Summary
Metabolic syndrome (MbS) significantly increases the risk of impaired cardiovascular autonomic function (CAF) in younger adults with type 2 diabetes (T2D). Poor glycaemic control and overweight are key contributing factors.
Area of Science:
- Cardiology
- Endocrinology
- Metabolic Diseases
Background:
- Type 2 diabetes (T2D) is frequently associated with metabolic syndrome (MbS).
- Impaired cardiovascular autonomic function (CAF) is a known complication of T2D.
- The interplay between T2D, MbS, and CAF in younger individuals requires further investigation.
Purpose of the Study:
- To determine the prevalence of impaired CAF in T2D patients under 55 years old.
- To analyze the relationship between impaired CAF and metabolic syndrome (MbS), BMI, waist circumference, HbA1c, hypertension, and family history.
- To assess the impact of glycaemic control and overweight on CAF in this population.
Main Methods:
- 180 T2D patients were studied.
- Metabolic syndrome (MbS) diagnosed using IDF criteria.
- Cardiovascular autonomic function (CAF) assessed using 5 tests via Cardionomic.
- Univariate and multivariate statistical analyses were performed.
Main Results:
- Prevalence of impaired CAF was 33.9% and MbS was 67.8%.
- Impaired CAF was significantly associated with MbS (86.9% of those with impaired CAF had MbS), overweight, and HbA1c > 7%.
- A positive linear correlation was observed between the degree of impaired CAF and BMI and HbA1c levels.
Conclusions:
- Glycaemic control and overweight significantly influence cardiovascular autonomic function (CAF) in T2D patients.
- The combination of T2D and MbS shows a stronger association with impaired CAF compared to T2D alone.
- MbS exacerbates cardiovascular risk and is linked to impaired CAF in younger T2D individuals.
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