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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Related Experiment Video

Updated: May 23, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Liver disorders in inflammatory bowel disease.

Victor Uko1, Suraj Thangada, Kadakkal Radhakrishnan

  • 1Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA.

Gastroenterology Research and Practice
|April 5, 2012
PubMed
Summary

Inflammatory bowel disease (IBD) can cause various liver and bile duct disorders, including primary sclerosing cholangitis. Some IBD medications and chronic inflammation also pose risks to liver health.

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Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Hepatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Hepatobiliary system disorders are common in inflammatory bowel disease (IBD) patients.
  • These can stem from shared disease pathways (e.g., primary sclerosing cholangitis) or complications of chronic inflammation and disease severity.
  • Medications for IBD, including sulfasalazine, thiopurines, and methotrexate, can negatively impact liver function.

Purpose of the Study:

  • To highlight the spectrum of hepatobiliary manifestations associated with inflammatory bowel disease.
  • To emphasize the importance of recognizing these conditions due to potential long-term consequences.
  • To underscore the need for multidisciplinary management of IBD-related liver disorders.

Main Methods:

  • Review of existing literature on IBD and hepatobiliary complications.
  • Analysis of etiological factors including shared pathogenesis, chronic inflammation, and medication side effects.
  • Discussion of clinical significance and management strategies.

Main Results:

  • Identified primary sclerosing cholangitis and small-duct PSC as IBD-associated conditions with shared pathogenesis.
  • Noted gallstones and portal vein thrombosis as consequences of chronic inflammation and IBD severity.
  • Confirmed potential hepatotoxicity of common IBD therapies.

Conclusions:

  • Hepatobiliary disorders are significant extraintestinal manifestations of IBD.
  • Awareness of these conditions is crucial for preventing serious long-term complications.
  • Effective management necessitates a collaborative, multidisciplinary approach for optimal patient outcomes.