Related Experiment Video
Updated: May 23, 2026
05:39
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
[A vomiting neonate]
Tim P Kelder1, Alfred H J van Meurs, Lyanne W Rövekamp-Abels
1Juliana Kinderziekenhuis, Den Haag, the Netherlands. t.p.kelder@lumc.nl
Nederlands Tijdschrift Voor Geneeskunde
|April 6, 2012
Summary
A neonate experienced vomiting due to pyloric obstruction. Surgical intervention, the Ramstedt procedure, successfully resolved the condition without complications.
Area of Science:
- Pediatric Surgery
- Neonatal Medicine
- Gastrointestinal Physiology
Background:
- Pyloric stenosis is a common cause of nonbilious vomiting in neonates.
- Early diagnosis and surgical intervention are crucial for favorable outcomes.
Observation:
- A 24-day-old male infant presented with postprandial vomiting.
- Physical examination revealed a prominent peristaltic wave, suggestive of gastric outlet obstruction.
- Diagnostic confirmation included capillary blood gas analysis and abdominal ultrasound.
Findings:
- The diagnostic findings confirmed infantile hypertrophic pyloric stenosis (IHPS).
- A successful Ramstedt pyloromyotomy was performed, achieving complete resolution of symptoms.
Implications:
- This case highlights the importance of prompt clinical evaluation for neonatal vomiting.
- The Ramstedt procedure remains a safe and effective treatment for pyloric stenosis.
- Timely surgical management ensures optimal growth and development in affected neonates.
More Related Videos
Related Concept Videos
01:22Pathophysiology of Vomiting
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...
01:11Pyloric Obstruction
Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
01:18Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
01:14Prevention of Further Absorption of Poison
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
01:07Intestinal Obstruction II: Pathophysiology
Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
01:29Acute Respiratory Failure-V
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...