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[Effect of pulsating electromagnetic field therapy on cell volume and phagocytosis activity in multiple sclerosis and
E Mix1, H L Jenssen, R Lehmitz
1Neurologische Abteilung, Universität Rostock.
Abstract:
PEMF treatment was studied in 10 patients with multiple sclerosis and 10 patients with migraine. In both patients' groups a single treatment induced a significant rise of yeast particle uptake by blood granulocytes. The percentage of phagocytizing cells was increased in migraine patients only. In both patients' groups 20 PEMF treatments caused a reduction of particle uptake, whereas the percentage of phagocytizing cells remained unchanged. In migraine patients the opsonic capacity of serum and the mean cell volume of erythrocytes, lymphocytes and granulocytes were initially reduced, but increased during the course of 20 PEMF treatments. The biphasic changes of cell volume and phagocytic activity are interpreted as a result of counter-regulation of the organism in response to the primary PEMF effect.
Insights
Pulsed electromagnetic field (PEMF) therapy initially boosted immune cell activity in multiple sclerosis and migraine patients. However, prolonged PEMF treatment led to reduced immune response, suggesting a biphasic effect.
Area of Science:
- Immunology
- Biophysics
Context:
- Investigating the immunomodulatory effects of Pulsed Electromagnetic Field (PEMF) therapy.
- Examining patient responses in neurological conditions like multiple sclerosis and migraine.
Purpose:
- To evaluate the impact of single and repeated PEMF treatments on granulocyte function and cellular parameters in patients with multiple sclerosis and migraine.
Summary:
- A single PEMF treatment significantly increased yeast particle uptake by blood granulocytes in both patient groups.
- Twenty PEMF treatments resulted in reduced particle uptake, with no change in phagocytic cell percentage.
- Migraine patients showed initial reductions in serum opsonic capacity and cell volumes, followed by increases during 20 PEMF treatments.
Impact:
- The study reveals a biphasic response to PEMF therapy, indicating a complex interaction between PEMF and the immune system.
- Findings suggest that PEMF's effects on cellular activity and volume may involve organismal counter-regulation.
- This research provides insights into PEMF's potential therapeutic mechanisms and side effects in neurological disorders.