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[Clinical usefulness of three quantitative D-dimers tests in outpatients with suspected deep vein thrombosis]

T Elías-Hernández1, R Otero-Candelera, D Fernández-Jiménez

  • 1Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío, Sevilla, España. teresaelias@telefonica.net

Revista Clinica Espanola
|April 6, 2012
PubMed

Insights

The ELISA mini-VIDAS® assay is effective for ruling out deep vein thrombosis (DVT) in outpatients with low clinical probability. This D-dimer test offers high sensitivity and negative predictive value, aiding in DVT diagnosis.

Area of Science:

  • Vascular Medicine
  • Diagnostic Imaging
  • Biochemistry

Context:

  • Deep vein thrombosis (DVT) diagnosis in outpatients relies on D-dimer (DD) testing.
  • Elevated DD levels lack specificity, but normal levels help rule out DVT.
  • Optimal quantitative DD assay selection for suspected lower limb DVT remains unclear.

Purpose:

  • To evaluate the clinical utility of three quantitative D-dimer assays (ELISA mini-VIDAS®, Acure-care DDMR, DD-Plus) in outpatients with suspected lower limb DVT.
  • To compare the concordance and diagnostic characteristics of these DD assays.
  • To identify the most effective assay for ruling out DVT in specific patient subgroups.

Summary:

  • A study included 306 outpatients with suspected lower limb DVT.
  • ELISA mini-VIDAS® and Acure-care DDMR showed the best concordance, high sensitivity, and negative predictive value.
  • ELISA mini-VIDAS® demonstrated superior performance in ruling out DVT for patients with low clinical probability.

Impact:

  • The ELISA mini-VIDAS® assay provides a reliable method for excluding DVT in low-risk outpatients.
  • This finding can streamline diagnostic pathways and potentially reduce unnecessary investigations.
  • Accurate DVT diagnosis impacts patient management and reduces the risk of thromboembolic events.
Abstract

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