Related Experiment Video
Updated: May 23, 2026
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
[A rare trauma-associated cause of central retinal vein occlusion in a young subject]
D A Mouinga Abayi1, J-M Giraud, J-R Fenolland
1Service d'ophtalmologie, hôpital d'Instruction des Armées du Val-de-Grâce, 74, boulevard Port-Royal, 75005 Paris, France. mouingaabayi@yahoo.fr
Introduction:
Retinal vein occlusions are the second leading cause of retinal vascular disease, after diabetic retinopathy. In the case of young subjects, a thorough etiological investigation must be conducted in order to diagnose rare etiologies, such as this heterozygous mutation of the factor II gene associated with a central retinal vein occlusion (CRVO), occurring in a young subject within the context of trauma.
Observation:
The case deals with a 35-year-old soldier on a mission in a conflict zone. He was the victim of blast injury as a result of the explosion of an improvised explosive device (IED) or homemade bomb, and presented a sudden decline in visual acuity in his left eye associated with the clinical picture of a CRVO. Analysis showed a heterozygous factor II G20210A gene mutation.
Conclusion:
Retinal vein occlusions are always serious visual events. In the case of young subjects, a thorough etiological investigation must be conducted in search of rare abnormalities likely to lead to retinal vein occlusion.
