Related Experiment Video
Updated: May 23, 2026

The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials
Published on: April 19, 2024
Fever of unknown origin: an evidence-based review
Kayoko Hayakawa1, Balaji Ramasamy, Pranatharthi H Chandrasekar
1Division of Infectious Diseases, Detroit Medical Center, Wayne State University, Detroit, MI 48201, USA. kayokohayakawa@gmail.com
Abstract:
Fever is a common problem for which patients seek medical advice. Fortunately, in most cases, fever is self-limiting or the etiology of fever is promptly established. Sustained, unexplained fever despite a comprehensive work up is recognized as fever of unknown origin (FUO), which frequently poses a clinical challenge. For a methodical approach, FUO is recently categorized into classic FUO, nosocomial FUO, neutropenic FUO and HIV-associated FUO based on the clinical setting and patient's underlying immune status. This review focuses on the key factors of classic FUO. The etiologic clues obtainable from the history, bedside physical examination findings and pertinent laboratory tests are discussed. Also, FUO in older patients and tuberculosis as a cause of FUO are briefly discussed.
Related Concept Videos
Types of Fever
Here are the different types of fever:
Methods of reducing fever
Pharmacological Methods of Reducing Fever:
Increased Body Temperature
Patterns of Fever
Investigation of Disease Outbreaks
Infectious Diseases and Their Occurrence
