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Updated: May 23, 2026

Multielectrode Array Recordings of the Vomeronasal Epithelium
Published on: March 1, 2010
Nanovesicle-based bioelectronic nose platform mimicking human olfactory signal transduction
Hye Jun Jin1, Sang Hun Lee2, Tae Hyun Kim3
1Department of Physics and Astronomy, Seoul National University, Seoul 151-747, Republic of Korea.
Abstract:
We developed a nanovesicle-based bioelectronic nose (NBN) that could recognize a specific odorant and mimic the receptor-mediated signal transmission of human olfactory systems. To build an NBN, we combined a single-walled carbon nanotube-based field effect transistor with cell-derived nanovesicles containing human olfactory receptors and calcium ion signal pathways. Importantly, the NBN took advantages of cell signal pathways for sensing signal amplification, enabling ≈ 100 times better sensitivity than that of previous bioelectronic noses based on only olfactory receptor protein and carbon nanotube transistors. The NBN sensors exhibited a human-like selectivity with single-carbon-atomic resolution and a high sensitivity of 1 fM detection limit. Moreover, this sensor platform could mimic a receptor-meditated cellular signal transmission in live cells. This sensor platform can be utilized for the study of molecular recognition and biological processes occurring at cell membranes and also for various practical applications such as food screening and medical diagnostics.
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