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Related Experiment Video

Updated: May 23, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Gliosarcoma with osseous tissue: an occasional metaplastic component.

Ila Tyagi1, Kaushik Majumdar, Sanjay Mehta

  • 1Department of Pathology, Academic Block, GB Pant Hospital, Jawaharlal Nehru Marg, New Delhi 110002, India.

Brain Tumor Pathology
|April 6, 2012
PubMed
Summary

This study reports a rare case of gliosarcoma, a brain tumor with glial and sarcomatous parts, exhibiting metaplastic osteoid formation. The findings contribute to understanding rare bone differentiation within these complex central nervous system neoplasms.

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Area of Science:

  • Neuro-oncology
  • Pathology
  • Radiology

Background:

  • Gliosarcomas are rare intrinsic central nervous system (CNS) neoplasms comprising glial and sarcomatous elements, constituting approximately 2% of glioblastomas.
  • Metaplastic osseous transformation within gliosarcomas is an exceptionally uncommon phenomenon, with limited documented cases.

Observation:

  • A 57-year-old male presented with a large, solid-cystic, heterogeneous left temporal lobe mass on MRI, showing peritumoral edema and calcifications.
  • Histopathological examination confirmed a World Health Organization (WHO) grade IV tumor with both neoplastic glial and mesenchymal components, characterized by myxoid changes and necrosis.
  • The sarcomatous areas notably displayed regions of benign osteoid formation.

Findings:

  • The case demonstrates gliosarcoma with metaplastic osteoid, a rare subtype of central nervous system (CNS) tumor.

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Last Updated: May 23, 2026

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  • Histology confirmed a grade IV glial and mesenchymal tumor with benign bone formation within sarcomatous areas.
  • The presence of osteoid highlights a rare metaplastic change in this rare brain tumor.

    • Implications:

    • The histogenesis of osseous elements in gliosarcomas remains unclear, potentially involving metaplastic change or divergent differentiation from a common progenitor.
    • Understanding the mechanisms of osseous differentiation in gliosarcomas is crucial for accurate diagnosis and potential therapeutic strategies.
    • This case expands the known spectrum of histological variations in gliosarcomas, emphasizing the importance of comprehensive pathological analysis.