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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Inflammation01:38

Inflammation

Overview
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

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Related Experiment Video

Updated: May 23, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Atherosclerosis, inflammation, genetics, and stem cells: 2012 update.

Pascal J Goldschmidt-Clermont1, Chunming Dong, David M Seo

  • 1Cardiology Division, Department of Medicine, Hussman Institute for Human Genomics, Leonard M. Miller School of Medicine, University of Miami, FL 33136, USA. pgoldschmidt@med.miami.edu

Current Atherosclerosis Reports
|April 6, 2012
PubMed
Summary
This summary is machine-generated.

New genetic discoveries reveal atherosclerosis involves complex inflammation and stem cell biology, not just traditional lipid pathways. These findings suggest arterial lesion development is more intricate than previously understood.

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On-Chip Endothelial Inflammatory Phenotyping
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On-Chip Endothelial Inflammatory Phenotyping

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Related Experiment Videos

Last Updated: May 23, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Area of Science:

  • Cardiovascular Biology
  • Inflammation Research
  • Genetics of Atherosclerosis

Background:

  • Atherosclerosis is an inflammatory disease influenced by lipoproteins, lifestyle factors (smoking, diabetes, hypertension), and genetics (40% risk).
  • Traditional research focused on lipid metabolism, diabetes, and hypertension as primary drivers of atherosclerosis.
  • Recent genetic studies have uncovered novel pathways implicated in the disease.

Purpose of the Study:

  • To investigate the genetic underpinnings of atherosclerosis beyond established risk factors.
  • To identify novel genes and pathways involved in the development of arterial lesions.
  • To re-evaluate the complexity of atherosclerosis pathogenesis.

Main Methods:

  • Genome-wide association studies (GWAS) were employed for unbiased gene discovery.
  • Analysis of genetic data post-human genome sequencing.
  • Comparison of newly identified genes with previously suspected pathways.

Main Results:

  • GWAS identified genes related to inflammation and stem cell biology, rather than solely lipid metabolism or traditional cardiac risk factors.
  • A minority of implicated genes were linked to lipid and other known cardiac risk factors.
  • The findings challenge the 'response to injury' hypothesis as a complete explanation for atherosclerosis.

Conclusions:

  • Atherosclerosis pathogenesis is more complex than a simple response to injury.
  • Inflammation and stem cell biology play critical roles, alongside traditional risk factors.
  • Novel genetic insights necessitate a broader understanding of atherosclerosis development.