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Published on: March 17, 2023
Vapor-induced phase transformations in docetaxel
Lakshmi Kumar Tatini1, K V S R Krishna Reddy, N Someswara Rao
1Analytical Development, Aptuit Laurus Pvt. Ltd., ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad, 500 078, India. kumarltatini@gmail.com
Abstract:
Vapor-induced transformations of docetaxel anhydrous (form D(A)) under ambient conditions have been studied using methanol, ethanol, and water as the solvent media. The online vapor-induced transformations were monitored by powder X-ray diffractometry. New solid forms (solvates/hydrates/anhydrous) of docetaxel anhydrous were obtained in stoichiometric ratios which were characterized completely using powder X-ray diffraction, differential scanning calorimeter, thermogravimetric analysis, and spectroscopic ((13)C solid-state nuclear magnetic spectroscopy, solution (1)H NMR, and Fourier transform infrared) techniques. The new forms namely methanol solvate (D(M)), ethanol solvate (D(E)), monohydrate (D(MH)), trihydrate (D(TH)), and anhydrous (D(AN-I) and D(AN-II)) were identified through structural analysis.
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