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Occult left ventricular dysfunction diagnosed by myocardial performance index in patients with limb girdle muscle
Rajashekar R Gurrala1, Venkata Mb Alla, Wilbert S Aronow
1Department of Cardiology, Nizam's Institute of Medical Sciences, Hyderabad, India.
Abstract:
The myocardial performance index (MPI) was assessed in 30 patients with limb girdle muscle dystrophy (LGMD) with a normal left ventricular ejection fraction (greater than 50%), as well as in 30 age- and sex-matched healthy adults with a left ventricular ejection fraction greater than 50%. MPIs derived by pulsed-wave Doppler and tissue Doppler were also compared. The MPI was 0.37±0.09 in the LGMD patients and 0.29±0.09 in the control group (P=0.003). These data show that patients with LGMD have occult cardiac dysfunction as evidenced by a higher MPI than the controls. There was good agreement between the MPIs measured by pulsed-wave Doppler and tissue Doppler methods in these patients.
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