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Published on: December 11, 2013
Borderline peripheral arterial disease
Päivi Korhonen1, Pertti Aarnio
1Central Satakunta Health Federation of Municipalities, Harjavalta, Finland. paivi.e.korhonen@fimnet.fi
Insights
The ankle-brachial index (ABI) can identify peripheral arterial disease (PAD). Borderline ABI values (0.91-1.00) may indicate subclinical cardiovascular disease, warranting further investigation for early risk identification.
Area of Science:
- Vascular Medicine
- Cardiovascular Diagnostics
- Atherosclerosis Research
Background:
- Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis, a leading global cause of death.
- Patients with PAD have increased cardiovascular comorbidity and a higher risk of fatal cardiovascular events.
- The ankle-brachial index (ABI) is a noninvasive test for PAD and a marker for subclinical cardiovascular disease (CVD).
Purpose of the Study:
- To review current knowledge on borderline PAD, defined by ABI values between 0.91 and 1.00.
- To explore the significance of ABI values conventionally regarded as 'no disease'.
- To highlight the potential of ABI for early identification of individuals at high risk for major CVD events.
Main Methods:
- Review of current literature and clinical guidelines on PAD diagnosis and risk stratification.
- Analysis of the diagnostic performance of the ankle-brachial index (ABI) for detecting PAD.
- Discussion of the implications of borderline ABI values (0.91-1.00) in cardiovascular risk assessment.
Main Results:
- Ankle-brachial index (ABI) values of 0.90 or less diagnose PAD at rest with high sensitivity and specificity.
- In individuals without PAD, ABI values are typically greater than 1.00.
- Borderline ABI values (0.91-1.00) may represent a state of subclinical atherosclerosis and increased cardiovascular risk.
Conclusions:
- Borderline ABI values (0.91-1.00) require further investigation as they may indicate subclinical cardiovascular disease.
- ABI testing holds promise for early identification of individuals at greatest risk for major cardiovascular events.
- Understanding the significance of borderline ABI values is crucial for comprehensive cardiovascular risk management.
Abstract:
Peripheral arterial disease (PAD), along with coronary artery disease and cerebrovascular disease, is a manifestation of systemic atherosclerosis. These cardiovascular diseases (CVDs) are the leading cause of death in the world, representing 30% of all global deaths. Although population-based studies indicate that PAD has a relatively benign course in the legs, patients with PAD show more cardiovascular comorbidity and have at least twofold risk of fatal coronary artery disease and cerebrovascular accidents compared with the general population. These studies suggest that noninvasive testing using the ankle-brachial index (ABI) is also an accurate marker of subclinical CVD and thus may hold promise for early identification of individuals at the greatest risk for major CVD events.The Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II) defines a cutoff ABI value of 0.90 or less for diagnosing PAD at rest. This threshold value has been reported to be 95% sensitive in detecting angiogram-positive PAD and almost 100% specific in identifying apparently healthy individuals. In persons without PAD, arterial pressures increase with greater distance from the heart, resulting in higher systolic blood pressures at the ankle than at the the brachial arteries. Thus, persons without atherosclerosis typically have an ABI greater than 1.00. But what is the significance of ABI values between 0.91 to 1.00, which are conventionally regarded as 'no disease'? The present article gives an overview of current knowledge of borderline PAD (ie, an ABI of 0.91 to 1.00).
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