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Updated: May 23, 2026

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14⁺ Monocytes

Published on: January 27, 2023

Inflammatory rheumatic disorders and bone.

Irene E M Bultink¹, Marijn Vis, Irene E van der Horst-Bruinsma

¹Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands. iem.bultink@vumc.nl

Current Rheumatology Reports

|April 6, 2012

Summary

Inflammatory joint diseases increase fracture risk due to bone loss. This review explores osteoimmunology and treatment options for osteoporosis in rheumatic conditions.

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Last Updated: May 23, 2026

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14⁺ Monocytes

Published on: January 27, 2023

Area of Science:

Osteoimmunology
Rheumatology
Bone Metabolism

Background:

Rheumatic diseases like rheumatoid arthritis, SLE, and ankylosing spondylitis cause bone loss and fractures.
Osteoporosis pathogenesis in these conditions is multifactorial, linked to inflammation and immobility.
Growing understanding of osteoimmunology highlights immune system's role in bone health.

Purpose of the Study:

To review the multifactorial pathogenesis of osteoporosis in inflammatory rheumatic diseases.
To discuss the role of osteoimmunology in bone loss associated with these conditions.
To present potential treatment options for clinicians managing fracture risk.

Main Methods:

Literature review focusing on osteoimmunology and osteoporosis in rheumatic diseases.
Analysis of factors contributing to increased fracture risk.
Synthesis of current and potential therapeutic strategies.

Main Results:

High disease activity and immobility significantly elevate fracture risk.
Age, BMI, and gender are additional background risk factors for fractures.
No intervention studies have yet demonstrated fracture reduction in this patient group.

Conclusions:

Osteoporosis in inflammatory rheumatic diseases is complex, involving immune, inflammatory, and lifestyle factors.
Understanding osteoimmunology is crucial for addressing bone loss.
Clinicians can consider presented treatment options to mitigate fracture risk.