Related Experiment Video
Updated: May 23, 2026

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
Published on: June 4, 2012
Cardiac device-related endocarditis: Epidemiology, pathogenesis, diagnosis and treatment - a review
Shimon Edelstein1, Malka Yahalom
1Unit of Infectious Disease;
Insights
Cardiac device-related endocarditis (CDE) is an increasing infection risk for patients with implanted cardiac devices. Prompt diagnosis and management, often involving device removal, are crucial to prevent severe complications and ensure patient safety.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Device Technology
Background:
- Cardiac device-related endocarditis (CDE) incidence is rising globally.
- CDE poses significant clinical challenges due to infection resistance and device dependency.
- Delayed management increases morbidity, mortality, and recurrence rates.
Purpose of the Study:
- To increase clinician awareness of cardiac device-related endocarditis.
- To outline an effective management strategy for CDE.
- To highlight the importance of timely intervention in CDE cases.
Main Methods:
- This review synthesizes current literature on CDE.
- It examines diagnostic criteria and treatment options.
- Focuses on the balance between device necessity and infection control.
Main Results:
- CDE often requires device and lead replacement.
- Infection is typically acquired during device insertion.
- Antibiotic resistance and high recurrence rates are common.
Conclusions:
- Early recognition and intervention are critical for managing CDE.
- A multidisciplinary approach is often necessary.
- Optimizing management strategies can improve patient outcomes.
Abstract:
Cardiac device-related endocarditis (CDE) is a phenomenon for which incidence is on the rise; it presents difficult management problems to the clinician. On one hand, there is the patient who needs the implanted device, and the potential morbidity and mortality associated with its removal. On the other hand, there is the problem of a persistent infection - usually acquired during insertion of an electrical device - that is resistant to many antibiotics, has a high recurrence rate, and necessitates an extensive operation to remove the device if removal is delayed. Most studies recommend device and metal lead replacement if CDE occurs. The aim of the present review is to raise awareness of CDE among clinicians, and to provide an appropriate approach to its management.
Related Concept Videos
Endocarditis I: Introduction
Endocarditis III: Medical Management
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis IV: Nursing Management
Cardiomyopathy V: Interprofessional Care
Rheumatic Heart Disease III: Medical Management

