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Published on: February 23, 2020
[Farmer's lung antigens in Germany]
J Sennekamp1, M Joest, I Sander
1Lungen- und Allergiezentrum Bonn in Malteser Trägerschaft, Bonn, Germany. joachim.sennekamp@malteser.org
Abstract:
Recent studies suggest that besides the long-known farmer's lung antigen sources Saccharopolyspora rectivirgula (Micropolyspora faeni), Thermoactinomyces vulgaris, and Aspergillus fumigatus, additionally the mold Absidia (Lichtheimia) corymbifera as well as the bacteria Erwinia herbicola (Pantoea agglomerans) and Streptomyces albus may cause farmer's lung in Germany. In this study the sera of 64 farmers with a suspicion of farmer's lung were examined for the following further antigens: Wallemia sebi, Cladosporium herbarum, Aspergillus versicolor, and Eurotium amstelodami. Our results indicate that these molds are not frequent causes of farmer's lung in Germany.
Insights
Farmer's lung can be caused by various microbes. This study investigated four additional molds, Wallemia sebi, Cladosporium herbarum, Aspergillus versicolor, and Eurotium amstelodami, but found they are not common causes of farmer's lung in Germany.
Area of Science:
- Pulmonary Medicine
- Immunology
- Environmental Health
Context:
- Farmer's lung is a hypersensitivity pneumonitis.
- Known causative agents include Saccharopolyspora rectivirgula, Thermoactinomyces vulgaris, and Aspergillus fumigatus.
- Other potential triggers like Absidia corymbifera and Erwinia herbicola have been identified in Germany.
Purpose:
- To investigate the role of Wallemia sebi, Cladosporium herbarum, Aspergillus versicolor, and Eurotium amstelodami as farmer's lung antigens.
- To assess the prevalence of these specific mold antigens in German farmers with suspected farmer's lung.
Summary:
- Sera from 64 farmers with suspected farmer's lung were tested for antibodies against Wallemia sebi, Cladosporium herbarum, Aspergillus versicolor, and Eurotium amstelodami.
- The study found no frequent association between these molds and farmer's lung in the studied German cohort.
- Results suggest these molds are unlikely to be significant contributors to farmer's lung cases in this region.
Impact:
- Provides crucial data on the etiological agents of farmer's lung in Germany.
- Helps refine diagnostic approaches by identifying less common or irrelevant antigens.
- Contributes to understanding the environmental triggers of hypersensitivity pneumonitis in agricultural settings.
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