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Plasma osteocalcin: biological variations and reference limits.

P Tarallo1, J Henny, B Fournier

  • 1Centre de Médecine Préventive, URA CNRS 597, Vandoeuvre-les-Nancy, France.

Scandinavian Journal of Clinical and Laboratory Investigation
|October 1, 1990
PubMed
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Plasma osteocalcin levels vary significantly with age and sex. This study provides reference ranges for osteocalcin (OC), a key bone protein, in healthy individuals across different life stages.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Bone Metabolism

Background:

  • Osteocalcin (OC) is the most abundant non-collagenous protein in bone matrix.
  • A portion of osteocalcin is released into the bloodstream.
  • Understanding OC levels is crucial for assessing bone health.

Purpose of the Study:

  • To measure plasma osteocalcin concentrations in a large cohort of healthy individuals.
  • To establish reference limits for plasma osteocalcin based on age and sex.
  • To investigate the influence of age, sex, and other factors on osteocalcin levels.

Main Methods:

  • Radioimmunoassay (RIA) was used to quantify plasma osteocalcin.
  • 1096 healthy subjects aged 4 to over 65 years were included.
  • Blood samples were collected from fasting subjects in the morning.

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Main Results:

  • Plasma osteocalcin levels were higher in men than in women initially.
  • Osteocalcin increased with age, weight, height, and bone age until adolescence (12-15 years).
  • In women over 50, osteocalcin levels increased and surpassed men's, remaining higher in older age groups.

Conclusions:

  • Plasma osteocalcin concentrations exhibit distinct age- and sex-dependent patterns.
  • Reference ranges for osteocalcin are provided, aiding clinical interpretation.
  • Factors like menstrual cycle and NSAIDs did not significantly affect plasma osteocalcin levels.