Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Delivery Pathways to the Lysosome

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...

Auditory Pathway

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...

Direct Motor Pathways

Direct Motor Pathways

The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and the...

Infection

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

Antigen Processing Pathways

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...

Streamlines, Streaklines, and Pathlines

Streamlines, Streaklines, and Pathlines

A streamline represents the trajectory that is always tangent to the fluid's velocity vector at any given point. The velocity of a fluid particle is always directed along the streamline, ensuring the particle continuously follows the streamline's path. Streamlines are particularly useful for visualizing the overall direction of flow in a fluid system, and they provide an instantaneous representation of the flow's velocity field. In steady flow, where conditions do not change over time,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Can ICER bring cost-effectiveness to drug prices?

Managed care (Langhorne, Pa.)·2019

Same author

A Mismatch Made in America.

Managed care (Langhorne, Pa.)·2019

Same author

Direct Contracting: Walmart Came a-Calling. Emory Answered.

Managed care (Langhorne, Pa.)·2019

Same author

Staying Mad: Walmart Gets Even-by Contracting Directly.

Managed care (Langhorne, Pa.)·2019

Same author

Prognosis? Misdiagnosis! The High Price of Getting It Wrong.

Managed care (Langhorne, Pa.)·2019

Same author

SOME DOCTORS FIND STRENGTH IN NUMBERS.

Physician leadership journal·2019

Same journal

Big pharma moves into biologics.

Biotechnology healthcare·2013

Same journal

Study: High Copayments Cut Biodrug Use up to 21 Percent.

Biotechnology healthcare·2013

Same journal

Avian flu and the quest for immunity: not just chicken feed.

Biotechnology healthcare·2013

Same journal

Variety of Biotech Therapies, Uses Take Prominence Among ASCO Presentations.

Biotechnology healthcare·2013

Same journal

Opening the door to follow-on proteins?

Biotechnology healthcare·2013

Same journal

On specialty pharmaceuticals: reflections of a second-year medical student.

Biotechnology healthcare·2013

See all related articles

Search research articles

Related Experiment Video

Updated: May 23, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

What path do we take?

Biotechnology Healthcare

|April 6, 2012

Summary

This summary is machine-generated.

Choosing the best biologic treatment is complex due to increasing options. Clinical effectiveness is key, but policy discussions must also consider treatment costs.

More Related Videos

Operation of the Collaborative Composite Manufacturing (CCM) System

Operation of the Collaborative Composite Manufacturing (CCM) System

Published on: October 1, 2019

Related Experiment Videos

Last Updated: May 23, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

Operation of the Collaborative Composite Manufacturing (CCM) System

Operation of the Collaborative Composite Manufacturing (CCM) System

Published on: October 1, 2019

Area of Science:

Pharmacology
Health Economics
Clinical Therapeutics

Background:

The expanding landscape of biologic therapies presents challenges for optimal patient treatment selection.
Increasing market availability of biologics necessitates careful consideration of therapeutic choices.

Purpose of the Study:

To address the complexities in selecting appropriate biologic treatments for patients.
To explore the integration of clinical effectiveness and cost considerations in treatment decisions.

Main Methods:

Literature review of current biologic treatment options.
Analysis of clinical effectiveness data for various biologics.
Examination of cost-effectiveness frameworks in healthcare policy.

Main Results:

Clinical effectiveness remains the primary criterion for individual patient treatment.
Cost-effectiveness analysis is crucial for policy-level decision-making regarding biologics.
Balancing efficacy with economic factors is essential for sustainable healthcare.

Conclusions:

Optimizing biologic therapy selection requires a dual focus on patient-specific clinical outcomes and broader economic impacts.
Healthcare policy must develop frameworks to incorporate both clinical efficacy and cost when evaluating biologic treatments.
Future strategies should aim for cost-effective biologic solutions without compromising patient care.