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Related Concept Videos

Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
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Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...
Biopharmaceutics and Pharmacokinetics: Overview01:28

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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the appropriate...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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Building a value-based approach to biologic drugs.

Janice L Clarke1, Alexis Skoufalos, David B Nash

  • 1Janice L. Clarke, RN, BBA, Alexis Skoufalos, EdD, and David B. Nash, MD, MBA, are affiliated with the Jefferson School of Population Health, in Philadelphia.

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Summary

Patient affordability of biologic therapies is a significant issue. A National Advisory Board convened to address challenges and propose solutions for payers regarding biologic drug access and cost.

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Area of Science:

  • Health economics
  • Pharmaceutical policy
  • Patient access to medication

Background:

  • Professional organizations lack comprehensive guidelines on biologic therapy affordability.
  • Patient access to essential biologic treatments is hindered by cost.
  • The Jefferson School of Population Health identified a critical need to address this issue.

Purpose of the Study:

  • To convene a National Advisory Board to discuss patient affordability of biologic therapies.
  • To quantify the challenges associated with the cost of biologic treatments.
  • To identify and recommend potential solutions for payers to improve affordability.

Main Methods:

  • Reconvening a National Advisory Board comprising experts.
  • Facilitating discussions to analyze the scope of the affordability problem.
  • Developing actionable strategies and recommendations for stakeholders.

Main Results:

  • The board identified key barriers to patient affordability of biologics.
  • Potential solutions were explored to mitigate the financial burden on patients.
  • A recommended approach for payers was formulated to enhance access.

Conclusions:

  • Addressing the affordability of biologic therapies requires a multi-faceted approach.
  • Payers have a crucial role in implementing solutions to improve patient access.
  • Further action is needed to ensure equitable access to biologic treatments.