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Related Concept Videos

Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Related Experiment Video

Updated: May 23, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Cyclic Cushing's syndrome.

R Krysiak1, A Kedzia, B Okopień

  • 1Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. r.krysiak@interia.pl

Acta Clinica Belgica
|April 7, 2012
PubMed
Summary
This summary is machine-generated.

Cyclic Cushing's syndrome involves fluctuating glucocorticoid levels, presenting diagnostic challenges due to intermittent symptoms. Early consideration of this adrenal disorder is crucial for timely diagnosis and management.

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Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
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Last Updated: May 23, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

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Published on: September 15, 2017

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

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Published on: April 25, 2016

Area of Science:

  • Endocrinology
  • Internal Medicine

Background:

  • Glucocorticoids are vital for life and homeostasis; adrenal disorders can be life-threatening if untreated.
  • Cyclic Cushing's syndrome is characterized by fluctuating glucocorticoid production, leading to periods of remission.

Observation:

  • Clinical and biochemical manifestations of cyclic Cushing's syndrome vary significantly between patients and over time.
  • The hypothalamic-pituitary-adrenal axis may appear undisturbed between symptomatic cycles.

Findings:

  • Cyclic Cushing's syndrome should be suspected in patients with hypercortisolism symptoms, normal glucocorticoid levels, and paradoxical dexamethasone test responses.
  • This report details a case of cyclic Cushing's syndrome, including diagnostic and treatment strategies.

Implications:

  • Timely diagnosis of cyclic Cushing's syndrome is essential to prevent serious health consequences.
  • Understanding the diagnostic nuances and treatment impacts is critical for managing this complex endocrine disorder.