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Updated: May 23, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Ligand effects on the stereochemical outcome of Suzuki-Miyaura couplings
Guo-Ping Lu1, Karl R Voigtritter, Chun Cai
1Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, USA.
Abstract:
The ligands associated with various Pd catalysts play a crucial role in determining the stereochemistry of cross-couplings between boronic acids and Z-alkenyl halides. A ligand on palladium has been found that leads to the desired products under mild conditions and in high yields that, in most cases, retain their Z-olefin geometry.
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