[Effects of tiaprofenic acid on nasal mucociliary transport time]

Mucociliary activity is a fundamental aspect of the clearance function of the respiratory tract; mucociliary transport time being the easiest parameter to record in regard to the overall, more complex function of nasal clearance. A double blind, multicenter randomized study was carried out on 40 rhinopathy patients divided into two groups and treated with tiaprofenic acid 300 mg or a placebo twice a day for seven consecutive days. Before and after treatment the following were recorded: subjective and objective nasal MCT time, using an original composition of vegetable charcoal powder and saccharin powder at 3%; nasal obstruction. The authors conclude that the treatment of rhinitis with tiaprofenic acid improved not only the clinical symptomatology but also the mucociliary transport time and rhinomanometric examination.