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No effect of creatine supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive
Christiano Rr Alves1, Igor H Murai, Pamella Ramona
1School of Physical Education and Sports, University of São Paulo, Av, Prof, Mello Moraes, 65, São Paulo, PO Box 05508-030, Brazil. gualano@usp.br.
Insights
Creatine supplementation did not reduce oxidative stress or improve cardiovascular health in spontaneously hypertensive rats. This study found no therapeutic benefits of creatine for hypertension-related oxidative stress.
Area of Science:
- Cardiovascular Research
- Oxidative Stress Biology
- Nutritional Supplementation Studies
Background:
- Arterial hypertension is linked to increased oxidative stress.
- Creatine (Cr) is investigated for potential antioxidant properties.
- Spontaneously hypertensive rats (SHR) are a model for studying hypertension.
Purpose of the Study:
- To evaluate the effects of creatine supplementation on oxidative stress.
- To assess creatine's impact on cardiovascular parameters in SHR.
- To determine if creatine offers therapeutic benefits for hypertension.
Main Methods:
- Nine-week supplementation trial with creatine or placebo in SHR.
- Measurement of lipid hydroperoxidation as an oxidative stress marker.
- Assessment of arterial blood pressure and heart structure.
Main Results:
- Creatine did not alter lipid hydroperoxidation levels in coronary artery, heart, plasma, plantaris, or EDL muscle.
- Arterial blood pressure remained unaffected by creatine supplementation.
- Heart structure showed no significant changes in response to creatine.
Conclusions:
- Creatine supplementation did not demonstrate therapeutic effects on oxidative stress in SHR.
- This study did not confirm creatine's benefits for cardiovascular dysfunction in hypertension.
- The findings do not support creatine as a treatment for hypertension-related oxidative stress.
Background:
Exacerbated oxidative stress is thought to be a mediator of arterial hypertension. It has been postulated that creatine (Cr) could act as an antioxidant agent preventing increased oxidative stress. The aim of this study was to investigate the effects of nine weeks of Cr or placebo supplementation on oxidative stress and cardiovascular parameters in spontaneously hypertensive rats (SHR).
Findings:
Lipid hydroperoxidation, one important oxidative stress marker, remained unchanged in the coronary artery (Cr: 12.6 ± 1.5 vs. Pl: 12.2 ± 1.7 nmol·mg-1; p = 0.87), heart (Cr: 11.5 ± 1.8 vs. Pl: 14.6 ± 1.1 nmol·mg-1; p = 0.15), plasma (Cr: 67.7 ± 9.1 vs. Pl: 56.0 ± 3.2 nmol·mg-1; p = 0.19), plantaris (Cr: 10.0 ± 0.8 vs. Pl: 9.0 ± 0.8 nmol·mg-1; p = 0.40), and EDL muscle (Cr: 14.9 ± 1.4 vs. Pl: 17.2 ± 1.5 nmol·mg-1; p = 0.30). Additionally, Cr supplementation affected neither arterial blood pressure nor heart structure in SHR (p > 0.05).
Conclusions:
Using a well-known experimental model of systemic arterial hypertension, this study did not confirm the possible therapeutic effects of Cr supplementation on oxidative stress and cardiovascular dysfunction associated with arterial hypertension.
