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Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Updated: May 23, 2026

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

Implant-induced microdamage in osteoporotic bone.

Zhi-Feng Yu¹, Ting-Ting Tang, Shi-Jing Qiu

¹Shanghai Key Laboratory of Orthopaedics Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 20001, China.

Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi

|April 7, 2012

Summary

Osteoporotic bone microdamage from implants impacts biomechanics. Bone remodeling and mineralization are key to repairing this damage, influencing implant stability.

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Area of Science:

Orthopedic Surgery
Biomaterials Science
Gerontology

Background:

Increasing elderly population necessitates more bone implant surgeries.
Osteoporotic bone is susceptible to microdamage during implant procedures.
Microdamage, including cracks and diffuse damage, affects bone biomechanics.

Purpose of the Study:

To summarize research on peri-implant microdamage in osteoporotic bone.
To highlight the impact of microdamage on bone quality and implant stability.
To review repair mechanisms and influencing factors.

Main Methods:

Literature review of peri-implant bone microdamage.
Analysis of factors affecting microdamage accumulation and repair.
Discussion of bisphosphonate effects on bone remodeling and microdamage.

Main Results:

Microcrack length and location significantly influence bone biomechanical performance.
Bisphosphonates can exacerbate microdamage accumulation, reducing bone strength.
Bone remodeling and mineralization are crucial for microdamage repair.

Conclusions:

Understanding microdamage is vital for long-term implant success in osteoporotic patients.
Bone quality and implant stability are directly linked to microdamage management.
Further research is needed on repair mechanisms and therapeutic interventions.