Related Experiment Video
Updated: May 23, 2026
The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
Published on: January 13, 2022
Comparison of muscle force after immediate and delayed reinnervation using nerve-muscle-endplate band grafting
Stanislaw Sobotka1, Liancai Mu
1Upper Airway Research Laboratory, Department of Research, Hackensack University Medical Center, Hackensack, New Jersey, USA. ssobotka@humed.com
Background:
Because of poor functional outcomes of currently used reinnervation methods, we developed novel treatment strategy for the restoration of paralyzed muscles-the nerve-muscle-endplate band grafting (NMEG) technique. The graft was obtained from the sternohyoid muscle (donor) and implanted into the ipsilateral paralyzed sternomastoid (SM) muscle (recipient).
Methods:
Rats were subjected to immediate or delayed (1 or 3 mo) reinnervation of the experimentally paralyzed SM muscles using the NMEG technique or the conventionally used nerve end-to-end anastomosis. The SM muscle at the opposite side served as a normal control.
Results:
NMEG produced better recovery of muscle force as compared with end-to-end anastomosis. A larger force produced by NMEG was most evident for small stimulation currents.
Conclusions:
The NMEG technique holds great potential for successful muscle reinnervation. We hypothesize that even better muscle reinnervation and functional recovery could be achieved with further improvement of the environment that favors axon-end plate connections and accelerates axonal growth and sprouting.
