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Pro-domain in precursor nerve growth factor mediates cell death

Arunmozhiarasi Armugam1, Dawn C I Koh, Chai Siaw Ching

  • 1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Neurochemistry International
|April 7, 2012
PubMed
Summary

The precursor Nerve Growth Factor (NGF) pro-domain induces cell death by mediating apoptosis through specific signaling pathways. Mature NGF and proNGF exhibit neurotrophic activity, unlike the pro-domain alone.

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