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Related Experiment Videos

Interaction studies with moclobemide.

R Zimmer1, R Gieschke, R Fischbach

  • 1Pharma Clinical Research, F. Hoffmann-La Roche, Basle, Switzerland.

Acta Psychiatrica Scandinavica. Supplementum
|January 1, 1990
PubMed
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Moclobemide, a reversible MAO inhibitor, shows a favorable drug interaction profile. It can be safely combined with many medications, including tricyclic antidepressants, unlike older MAO inhibitors.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Neuroscience

Background:

  • Moclobemide is a reversible inhibitor of monoamine oxidase (MAO).
  • Understanding drug interactions is crucial for safe moclobemide use in patients with depression.
  • Older irreversible MAO inhibitors posed significant interaction risks.

Purpose of the Study:

  • To review drug interactions associated with moclobemide.
  • To assess the safety of combining moclobemide with various drug classes.
  • To compare moclobemide's interaction profile with older MAO inhibitors.

Main Methods:

  • Review of safety studies in healthy subjects and depressed patients.
  • Investigation of interactions with antihypertensives, digoxin, oral contraceptives, anticoagulants, and benzodiazepines.

Related Experiment Videos

  • Pharmacokinetic study with cimetidine and interaction study with alcohol and sympathomimetics.

    • Main Results:

    • Moclobemide showed no clinically relevant interactions with antihypertensives, digoxin, oral contraceptives, anticoagulants, or benzodiazepines.
    • Combined use with tricyclic antidepressants (amitriptyline, desipramine) was well-tolerated without requiring dose adjustments or therapy-free intervals.
    • Cimetidine approximately doubled moclobemide plasma concentration, necessitating cautious dosing.
    • No significant interaction with alcohol was observed at therapeutic doses (100-300 mg/day).

    Conclusions:

    • Moclobemide exhibits a favorable safety profile regarding drug interactions.
    • It can be safely substituted for or co-administered with certain tricyclic antidepressants.
    • Caution is advised when combining moclobemide with cimetidine due to pharmacokinetic interactions.
    • Moclobemide offers a safer alternative to irreversible MAO inhibitors in clinical practice.