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Updated: May 23, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse
Santosh N Mokale1, Deepak Lokwani, Devanand B Shinde
1Dr. Rafiq Zakaria Campus, YB Chavan College of Pharmacy, Aurangabad, Maharashtra, India.
Abstract:
A novel series of substituted imidazol-5-ones were designed, synthesized and evaluated for in vitro reverse transcriptase (RT) inhibition activity using reverse transcriptase assay kit (Roche, Colorimetric). It has been observed from in vitro screening that newly synthesized compounds possess RT inhibitory activity. Docking study was performed to study the binding orientation and affinity of synthesized compounds for RT enzyme.
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