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Related Experiment Video

Updated: May 23, 2026

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Published on: January 5, 2021

The metabolism beyond programmed cell death in yeast.

Julia Ring¹, Cornelia Sommer, Didac Carmona-Gutierrez

¹Institute of Molecular Biosciences, University of Graz, Graz, Austria.

Experimental Cell Research

|April 7, 2012

Summary

Cellular fate, whether survival or programmed cell death, hinges on metabolic status. The yeast Saccharomyces cerevisiae model reveals how metabolic changes influence stress defense, cell death, and longevity.

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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

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Published on: September 26, 2025

Area of Science:

Cell Biology
Metabolic Engineering
Biochemistry

Background:

Cellular responses to environmental changes involve complex pathways leading to adaptation or programmed cell death.
Metabolic status is a key determinant of a cell's fate, influencing its physiological, developmental, and pathological states.
The metabolome, encompassing all metabolites, provides critical insights into cellular condition and stress response.

Purpose of the Study:

To explore how metabolic status influences cell survival and death pathways.
To highlight the utility of Saccharomyces cerevisiae as a model organism for studying metabolism-linked cellular processes.
To review recent findings on stress defense, apoptosis, and longevity using yeast models.

Main Methods:

Utilizing Saccharomyces cerevisiae to manipulate and monitor metabolic conditions, such as altering nutrient sources.
Employing genetic modifications, including single gene disruptions and mitochondrial DNA abrogation, to induce respiratory deficiency.
Analyzing the impact of metabolic changes on cellular fate, stress response, and apoptosis.

Main Results:

Metabolic state significantly impacts the decision between cell survival and programmed cell death.
Saccharomyces cerevisiae serves as a powerful model for investigating (patho)physiological scenarios like caloric restriction and the Warburg effect.
Disruptions in metabolism and mitochondrial function are linked to altered apoptosis and longevity.

Conclusions:

Metabolic status is a central regulator of cellular fate, influencing stress defense, apoptosis, and longevity.
The yeast model provides a tractable system for dissecting the intricate relationship between metabolism and cell death.
Further research in yeast can yield significant insights into fundamental biological processes relevant to human health and disease.