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Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
Published on: September 12, 2018
Spectroscopic and spectrofluorimetric studies on the interaction of albendazole and trimethoprim with iodine
1Department of Chemistry, Gandhigram Rural Institute (Deemed University), Gandhigram 624 302, India.
Abstract:
Raman, UV-vis, FT-IR, and fluorescence spectral techniques were employed to investigate the mechanism of interaction of albendazole (ALB) and trimethoprim (TMP) drugs with iodine. Interactions of ALB and TMP with iodine yields triiodide ion and its formation was confirmed by electronic and Raman spectra. The peaks appeared in Raman spectra of the isolated products are at around 145, 113 and 82 cm(-1) are assigned to ν(as)(I-I), ν(s)(I-I) and δ(I(3)(-)) respectively, confirmed the presence of I(3)(-) ion. Formation constant (K), molar extinction coefficient (ɛ) and thermodynamic properties ΔH(#), ΔS(#) and ΔG(#) were determined and discussed. Fluorescence quenching studies indicated that the interaction between the ALB, TMP with iodine are spontaneous and the TMP-iodine interaction is found to be stronger than that the other system. Solvent variation studies indicated that the binding constant increased with an increase in polarity of the medium.
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