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Updated: May 23, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a
Danni Shi1, Shizhi Wang, Dongying Gu
1The Key Laboratory of Modern Toxicology of Ministry of Education, Department of Molecular and Genetic Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Purpose:
Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol-anchored 123-aa protein related to the cell-proliferation inhibition and/or cell-death induction activity. Many studies had reported the role of PSCA rs2294008 C > T and rs2976392 G > A polymorphisms on gastric cancer risk.
Methods:
To investigate a more precise estimation of the relationships, we performed a meta-analysis on 9 case-control studies included 10,746 cases and 9,158 controls. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the association.
Results:
For PSCA rs2294008 C > T polymorphism, there was a significantly increased risk of gastric cancer in all genetic models (TT/TC vs. CC: OR = 1.61, 95 % CI = 1.35-1.91; TT vs.
Tc/Cc:
OR = 1.33, 95 % CI = 1.24-1.42). Similar results were also observed for PSCA rs2976392 G > A polymorphism (AA/AG vs. GG: OR = 1.69, 95 % CI = 1.24-2.31; AA vs.
Ag/Gg:
OR = 1.36, 95 % CI = 1.24-1.50). In the stratified analysis by ethnicity of rs2294008, an increased gastric cancer risk was found in both Asians (TT vs.
Tc/Cc:
OR = 1.31, 95 % CI = 1.22-1.42) and Europeans (TT/TC vs. CC: OR = 1.42, 95 % CI = 1.18-1.71). Furthermore, when stratified by clinicopathologic characteristics of tumor location and histology, a higher risk on non-cardia compared with cardia gastric cancer (TT vs.
Tc/Cc:
OR = 1.43, 95 % CI = 1.12-1.83) as same as diffused compared with intestinal gastric cancer (TT vs.
Tc/Cc:
OR = 1.29, 95 % CI = 1.13-1.49) was observed.
Conclusion:
These findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer.
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