Related Experiment Video
Updated: May 23, 2026
06:45
In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
Published on: July 2, 2020
Properties of nanoparticles prepared from NdFeB-based compound for magnetic hyperthermia application
E A Périgo1, S C Silva, E M B de Sousa
1Center for Process and Product Technology, Institute of Technological Research, São Paulo, SP 05508-901, Brazil. eaperigo@ieee.org
Nanotechnology
|April 7, 2012
Summary
NdFeB nanoparticles, processed for magnetic hyperthermia, show promising heating capabilities. Their acceptable cytotoxicity makes them suitable for potential therapeutic applications.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Magnetic nanoparticles are explored for targeted cancer therapy.
- Neodymium-Iron-Boron (NdFeB) alloys offer strong magnetic properties.
- Controlling nanoparticle characteristics is crucial for hyperthermia efficacy.
Purpose of the Study:
- To synthesize and characterize NdFeB nanoparticles for magnetic hyperthermia.
- To evaluate their heating efficiency under alternating magnetic fields.
- To assess the in vitro cytotoxicity of the prepared nanoparticles.
Main Methods:
- Hydrogen decrepitation and high-energy ball milling of NdFeB alloy.
- Magnetic property measurements (magnetic moment, coercivity).
- In vitro hyperthermia testing in aqueous solutions and cytotoxicity assays.
Main Results:
- Nanoparticles exhibited magnetic moments >70 A m(2)/kg with coercivity <20 kA/m.
- Heating of solutions reached ΔT(max) of 26–44 K, with SAR up to 225 W/kg.
- Pure magnetic material (10h milling) showed SAR ~2500 W/kg.
- Cytotoxicity tests revealed acceptable biocompatibility (0.1–100 µg/mL).
Conclusions:
- NdFeB nanoparticles are effective heating agents for magnetic hyperthermia.
- The milling process influences magnetic properties and heating efficiency.
- The synthesized nanoparticles demonstrate good biocompatibility for potential biomedical use.
Related Concept Videos
01:31Ferromagnetism
Materials like iron, nickel, and cobalt consist of magnetic domains, within which the magnetic dipoles are arranged parallel to each other. The magnetic dipoles are rigidly aligned in the same direction within a domain by quantum mechanical coupling among the atoms. This coupling is so strong that even thermal agitation at room temperature cannot break it. The result is that each domain has a net dipole moment. However, some materials have weaker coupling, and are ferromagnetic at lower...
01:31Magnetic Susceptibility and Permeability
In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
01:30Paramagnetism
Paramagnets are materials with unpaired electrons that possess a finite magnetic moment. In the absence of a magnetic field, these moments are randomly oriented, and thus the net moment is zero. Under an external field, a torque acting on the moments tends to align them along the field's direction. However, the random thermal motion of electrons produces a torque opposite to the external field and tries to disorient the moments. These two competing effects align only a few moments along the...