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Updated: May 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Psoriasis and cardiovascular disorders

C Ryan1, A Menter

  • 1Department of Dermatology, Baylor University Medical Center, Dallas, TX, USA. caitriona.ryan@baylorhealth.edu

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia
|April 7, 2012
PubMed

Insights

Patients with moderate-to-severe psoriasis face higher cardiovascular disease risks due to shared inflammatory pathways. Psoriasis treatments may impact cardiovascular health, requiring careful consideration of therapy choices.

Area of Science:

  • Dermatology and Cardiology
  • Inflammation and Immunology

Background:

  • Moderate-to-severe psoriasis is linked to increased cardiovascular disease (CVD) risk and associated factors like obesity and diabetes.
  • Shared inflammatory pathways are implicated in the pathophysiology of psoriasis, obesity, and coronary artery disease.

Purpose of the Study:

  • To review the association between psoriasis and cardiovascular disorders.
  • To evaluate the impact of current psoriasis therapies on cardiovascular risk.

Main Methods:

  • Review of existing evidence on psoriasis and cardiovascular comorbidities.
  • Analysis of studies on the cardiovascular effects of psoriasis treatments, including methotrexate, anti-TNF-a agents, and anti-interleukin-12p40 antibodies.

Main Results:

  • Retrospective studies suggest potential cardio-protective effects of methotrexate and anti-TNF-a agents.
  • Concerns exist regarding potential excess cardiovascular events with newer anti-interleukin-12p40 antibody therapies.

Conclusions:

  • Understanding the link between psoriasis and CVD is crucial for patient management.
  • The choice of psoriasis therapy may influence cardiovascular risk, necessitating further investigation.

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