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Updated: May 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Psoriasis and cardiovascular disorders.

C Ryan¹, A Menter

¹Department of Dermatology, Baylor University Medical Center, Dallas, TX, USA. caitriona.ryan@baylorhealth.edu

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia

|April 7, 2012

Summary

This summary is machine-generated.

Patients with moderate-to-severe psoriasis face higher cardiovascular disease risks due to shared inflammatory pathways. Psoriasis treatments may impact cardiovascular health, requiring careful consideration of therapy choices.

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Last Updated: May 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology and Cardiology
Inflammation and Immunology

Background:

Moderate-to-severe psoriasis is linked to increased cardiovascular disease (CVD) risk and associated factors like obesity and diabetes.
Shared inflammatory pathways are implicated in the pathophysiology of psoriasis, obesity, and coronary artery disease.

Purpose of the Study:

To review the association between psoriasis and cardiovascular disorders.
To evaluate the impact of current psoriasis therapies on cardiovascular risk.

Main Methods:

Review of existing evidence on psoriasis and cardiovascular comorbidities.
Analysis of studies on the cardiovascular effects of psoriasis treatments, including methotrexate, anti-TNF-a agents, and anti-interleukin-12p40 antibodies.

Main Results:

Retrospective studies suggest potential cardio-protective effects of methotrexate and anti-TNF-a agents.
Concerns exist regarding potential excess cardiovascular events with newer anti-interleukin-12p40 antibody therapies.

Conclusions:

Understanding the link between psoriasis and CVD is crucial for patient management.
The choice of psoriasis therapy may influence cardiovascular risk, necessitating further investigation.