Psoriasis and cardiovascular comorbidities with emphasis in Asia
1Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan. tftsai@yahoo.com
Summary
Psoriasis patients face increased cardiovascular risks due to chronic inflammation and metabolic syndrome. Treatments, including biologics, may impact these risks, with emerging Taiwanese research contributing to this field.
Area of Science:
- Dermatology
- Cardiology
- Immunology
Background:
- Psoriasis, traditionally viewed as a skin condition, is increasingly linked to systemic comorbidities.
- Cardiovascular disease is a significant concern in psoriasis patients, impacting mortality and treatment strategies.
- Shared inflammatory pathways, including Th1 and Th17 responses, and metabolic factors like adiposity and metabolic syndrome, may underlie both psoriasis and atherosclerosis.
Purpose of the Study:
- To review current literature on cardiovascular risks associated with psoriasis.
- To examine the impact of psoriasis treatments, including biologics, on cardiovascular comorbidities.
- To present recent findings, including those from Taiwan, addressing the cardiovascular risks in psoriasis.
Main Methods:
- Literature review of recent publications on psoriasis and cardiovascular comorbidities.
- Analysis of studies investigating the effects of psoriasis treatments on cardiovascular health.
- Inclusion of recent research data from Taiwan.
Main Results:
- Growing evidence confirms a significant link between psoriasis and cardiovascular comorbidities.
- Chronic inflammation and metabolic syndrome are implicated as common pathogenic mechanisms.
- Psoriasis treatments, particularly biologics, are being investigated for their cardiovascular effects.
Conclusions:
- Psoriasis is associated with increased cardiovascular risk, extending beyond its dermatological manifestations.
- Understanding shared inflammatory and metabolic pathways is crucial for managing comorbidities.
- Further research, including Asian-specific data, is needed to fully elucidate and manage cardiovascular risks in psoriasis patients.
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