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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Primary systemic amyloidosis associated with multiple myeloma.
Ederson Valei Lopes de Oliveira1, Ana Carolina Garcia Pozetti, Eurides Maria de Oliveira Pozetti
1Medical School, Faculdade de Medicina de São José do Rio Preto, SP, Brazil. edersonvlo@yahoo.com.br
Anais Brasileiros De Dermatologia
|April 7, 2012
Summary
This case report details a 48-year-old female with simultaneous systemic amyloidosis and multiple myeloma. Cutaneous amyloid lesions preceded the multiple myeloma diagnosis, highlighting skin manifestations in this rare dual diagnosis.
Area of Science:
- Dermatology
- Hematology
- Pathology
Background:
- Systemic amyloidosis and multiple myeloma are distinct plasma cell disorders.
- Cutaneous involvement in amyloidosis can manifest as infiltrative lesions.
Observation:
- A 48-year-old female presented with cutaneous amyloid lesions on the eyelids, neck, and retroauricular region.
- Skin biopsy revealed amorphous, eosinophilic deposits confirmed as amyloid by Congo red staining.
- Patient exhibited proteinuria, Bence-Jones proteinuria, and 70% clonal plasma cells in myelogram.
Findings:
- The patient was diagnosed with multiple myeloma based on the presence of amyloid skin lesions.
- Simultaneous occurrence of systemic amyloidosis and multiple myeloma was confirmed.
Implications:
- Cutaneous amyloidosis can be an early indicator of underlying multiple myeloma.
- Early recognition of skin lesions may aid in timely diagnosis of hematologic malignancies.
- This case underscores the importance of a multidisciplinary approach in diagnosing complex plasma cell disorders.
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