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Related Experiment Video

Updated: May 23, 2026

Investigating the Phagocytosis of Leishmania using Confocal Microscopy

Investigating the Phagocytosis of Leishmania using Confocal Microscopy

Published on: July 29, 2021

Periungual leishmaniasis.

Ciro Martins Gomes¹, Orlando Oliveira de Morais, Anglya Samara Silva Leite

¹University Hospital of Brasilia, University of Brasilia, DF, Brazil. ciro_m_gomes@yahoo.com.br

Anais Brasileiros De Dermatologia

|April 7, 2012

Summary

Cutaneous leishmaniasis typically affects limbs. This case details a rare finger infection successfully treated with pentoxifylline after antimony failure, highlighting therapeutic challenges.

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Area of Science:

Dermatology
Infectious Diseases
Parasitology

Background:

Cutaneous leishmaniasis (CL) is a parasitic disease primarily affecting exposed skin, often on limbs.
Leishmania species, particularly those from the Viannia subgenus, cause CL and can present diagnostic and therapeutic challenges.

Observation:

A rare case of CL occurred on the fourth finger of the left hand in a female patient with occupational exposure in a forested area.
The patient presented with a characteristic ulcer with infiltrated borders, indicative of CL.

Findings:

Diagnosis confirmed CL caused by Leishmania (Viannia).
Initial treatment with antimony was ineffective.
Combination therapy with antimony and pentoxifylline resulted in clinical cure.

Implications:

This case underscores the unusual periungual (around the nail) presentation of CL.
It highlights the potential for pentoxifylline to enhance treatment efficacy in refractory CL cases.
The findings suggest a need for considering alternative therapeutic strategies for difficult-to-treat CL presentations.