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Published on: September 15, 2023
Perioperative mortality in diabetic patients undergoing coronary artery bypass graft surgery
Michel Pompeu Barros de Oliveira Sá1, Evelyn Figueira Soares, Cecília Andrade Santos
1General Surgery, Barao de Lucena Hospital, Brazil. michel_pompeu@yahoo.com.br
Insights
Diabetic patients undergoing Coronary Artery Bypass Grafting (CABG) face higher in-hospital death risks from on-pump procedures and low cardiac output. Internal thoracic artery use offers protection.
Area of Science:
- Cardiovascular Surgery
- Diabetic Patient Outcomes
- Surgical Risk Factors
Background:
- Diabetic patients undergoing Coronary Artery Bypass Grafting (CABG) represent a high-risk surgical population.
- Identifying specific risk factors for in-hospital mortality is crucial for improving patient outcomes.
Purpose of the Study:
- To investigate independent risk factors associated with in-hospital death in diabetic patients undergoing isolated CABG.
- To identify potential protective factors that may reduce mortality.
Main Methods:
- A retrospective analysis of 305 diabetic patients who underwent CABG between April 2004 and April 2010.
- Univariate analysis followed by backward logistic regression for multivariate analysis to identify significant risk factors (p <0.05).
Main Results:
- The in-hospital mortality rate was 11.8%.
- Independent risk factors for death included on-pump CABG (OR 6.15) and postoperative low cardiac output (OR 34.17).
- Internal thoracic artery (ITA) use was a significant protective factor (OR 0.27).
Conclusions:
- On-pump CABG and low cardiac output syndrome are significant independent risk factors for in-hospital death in diabetic patients.
- The use of the internal thoracic artery (ITA) demonstrates a protective effect against mortality after CABG.
Objective:
To investigate the risk factors for in-hospital death in diabetic patients undergoing isolated Coronary Artery Bypass Grafting (CABG).
Methods:
We conducted a retrospective study with 305 consecutive diabetic patients undergoing CABG in the Division of Cardiovascular Surgery of our institution from April 2004 to April 2010. Univariate analysis for categorical variables was performed with the chi-square or Fisher's exact test, as appropriate. Potential risk factors with p <0.05 in the univariate analysis were included in the multivariate analysis, which was performed by backward logistic regression. Values of p <0.05 were considered statistically significant.
Results:
The study population had a mean age of 61.44 years (± 9.81) and 65.6% (n=200) were male. The in-hospital mortality rate was 11.8% (n=36). The following independent risk factors for death were identified: on-pump CABG (OR 6.15, 95% CI 1.57 to 24.03, P=0.009) and low cardiac output in the postoperative period (OR 34.17, 95% CI 10.46 to 111.62, P <0.001). The use of internal thoracic artery (ITA) was an independent protective factor for death (OR 0.27, 95% CI 0.08 to 0.093, P=0.038).
Conclusion:
This study identified the following independent risk factors for death after CABG: on-pump CABG and low cardiac output syndrome. The use of ITA was an independent protective factor.
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