Related Experiment Video
Updated: May 23, 2026
An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
Published on: December 7, 2016
The effects of injection site on the reflux following intravitreal injections
Burak Turgut1, Tamer Demir, Ulku Celiker
1Firat University School of Medicine, Department of Ophthalmology, Elazig, Turkey.
Background:
This study aimed to investigate the effects of injection site on the reflux after intravitreal injection.
Methods:
One hundred and eighty eyes undergoing intravitreal injection including 0.1 ml of triamcinolone acetonide or bevacizumab or pegaptanib were divided to six groups (30 patients in each group) to compare the vitreal reflux after injection using superotemporal versus inferotemporal quadrant. The amount of intraoperative reflux was estimated by measuring the width of the subconjunctival bleb. An interventional, prospective, comparative clinical trial was applied.
Results:
The mean bleb width as the reflux amount after injection of three drugs was statistically less after the inferotemporal injection (1.50 ± 0.94 mm for triamcinolone acetonide, p < 0.001; 1.60 ± 1.07 mm for bevacizumab, p < 0.001; and 1.77 ± 0.94 mm for pegaptanib, p = 0.001) than those in eyes undergoing the superotemporal injection (3.20 ± 1.63 mm for triamcinolone acetonide; 3.07 ± 1.53 mm for bevacizumab; and 2.80 ± 1.32 mm for pegaptanib).
Conclusions:
The injection through inferotemporal quadrant provides statistically significant less vitreal reflux for intravitreal drug injection.
Keywords:
Intravitreal injection; Injection site; Reflux.
Related Concept Videos
01:19Imaging Studies VII: Vascular Imaging
01:21Drug Accumulation During Multiple Dosing: Repetitive IV Injections