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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...

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Related Experiment Video

Updated: May 23, 2026

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
04:01

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

Published on: June 14, 2024

Myocardial dysfunction in sepsis: a large, unsolved puzzle.

Constantino Jose Fernandes1, Murillo Santucci Cesar de Assuncao

  • 1Hospital Israelita Albert Einstein, Avenida Albert Einstein 627/701, 05661-901 Morumbi, SP, Brazil.

Critical Care Research and Practice
|April 7, 2012
PubMed
Summary
This summary is machine-generated.

Sepsis can cause cardiac depression and myocardial dysfunction, impacting survival. This review explores the mechanisms and diagnostic biomarkers for cardiac issues in sepsis, though their clinical impact needs further study.

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Last Updated: May 23, 2026

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
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A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Sepsis is a global health concern with high mortality.
  • Cardiac dysfunction is a significant complication of sepsis.
  • The precise mechanisms of myocardial depression in sepsis require further investigation.

Purpose of the Study:

  • To review the anatomical, histopathological, and pathophysiological mechanisms of cardiac dysfunction in sepsis.
  • To summarize current understanding of cardiac depression during sepsis.
  • To evaluate the utility of biomarkers in detecting cardiac issues in sepsis.

Main Methods:

  • Literature review of anatomical, histopathological, and pathophysiological studies.
  • Analysis of research on sepsis-induced myocardial dysfunction.
  • Examination of biomarker studies for cardiac depression in sepsis.

Main Results:

  • Cardiac dysfunction in sepsis involves complex anatomical, histopathological, and pathophysiological changes.
  • Existing biomarkers can detect cardiac depression, but their clinical significance is not fully established.
  • Further research is needed to clarify the role and impact of these biomarkers.

Conclusions:

  • Cardiac depression is a critical component of sepsis pathophysiology.
  • Understanding the mechanisms of cardiac dysfunction is crucial for improving sepsis outcomes.
  • The clinical utility of cardiac biomarkers in sepsis management requires further validation.