Search research articles

Search research articles

Related Experiment Video

Updated: May 23, 2026

Dynamic Assessments of Coronary Flow Reserve after Myocardial Ischemia Reperfusion in Mice

Dynamic Assessments of Coronary Flow Reserve after Myocardial Ischemia Reperfusion in Mice

Published on: August 25, 2023

MicroRNAs in Postischemic Vascular Repair.

Andrea Caporali¹, Costanza Emanueli

¹Laboratory of Vascular Pathology and Regeneration, Regenerative Medicine Section, School of Clinical Sciences, Bristol Heart Institute, University of Bristol, Bristol, BS2 8HW, UK.

Cardiology Research and Practice

|April 7, 2012

Summary

MicroRNAs (miRNAs) regulate blood vessel growth after ischemia. This study explores miRNA roles in endothelial cells and their potential as biomarkers for ischemic diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Marchetti et al. MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles. <i>Int. J. Mol. Sci</i>. 2020, <i>21</i>, 1733.

International journal of molecular sciences·2026

Same author

A Topological Fingerprint Encodes Motor Skill at Rest.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026

Same author

Intercellular transport of miR-146a from macrophages to vascular smooth muscle cells: a novel mechanism and therapeutic target for atherosclerosis.

Cardiovascular research·2026

Same author

Severe hypoxia drives loss of ST6GAL1-mediated α2,6-sialylation in the epicardial secretome impairing angiogenic activity.

Biology open·2026

Same author

Interleukin 11-Induced MicroRNAs as Functional Mediators and Circulating Biomarkers of Cardiac Fibrosis.

Circulation research·2026

Same author

Senescence-related myocardial dysfunction: keeping a young heart.

European heart journal·2026

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Area of Science:

Cardiovascular Biology
Molecular Biology
Biomedical Science

Background:

Angiogenesis is crucial for development and adult tissue repair, but also implicated in diseases like cancer and diabetic retinopathy.
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression, impacting various biological processes.
Dysregulation of angiogenesis contributes to pathological conditions, highlighting the need for understanding its molecular control.

Purpose of the Study:

To elucidate the function of miRNAs in postischemic angiogenesis.
To describe miRNA regulation and expression in endothelial cells.
To explore the potential of circulating miRNAs as biomarkers for ischemic diseases.

Main Methods:

Review of existing literature on miRNA function in endothelial cells.

More Related Videos

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

Published on: November 8, 2019

Related Experiment Videos

Last Updated: May 23, 2026

Dynamic Assessments of Coronary Flow Reserve after Myocardial Ischemia Reperfusion in Mice

Dynamic Assessments of Coronary Flow Reserve after Myocardial Ischemia Reperfusion in Mice

Published on: August 25, 2023

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

Published on: November 8, 2019

Analysis of miRNA involvement in postischemic vascular repair mechanisms.

Discussion of current research on circulating miRNAs in ischemic conditions.

Main Results:

miRNAs are key regulators of endothelial cell function and angiogenesis.
Specific miRNAs have been identified that promote or inhibit postischemic vascular repair.
Circulating miRNAs show promise as non-invasive biomarkers for diagnosing and monitoring ischemic diseases.

Conclusions:

miRNAs play a critical role in modulating postischemic angiogenesis and vascular repair.
Targeting specific miRNAs could offer novel therapeutic strategies for ischemic conditions.
Circulating miRNAs represent a valuable, accessible resource for early detection and prognosis of ischemic diseases.