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Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
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Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...
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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Related Experiment Video

Updated: May 23, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Shilajit: a natural phytocomplex with potential procognitive activity.

Carlos Carrasco-Gallardo1, Leonardo Guzmán, Ricardo B Maccioni

  • 1Laboratory of Cellular and Molecular Neurosciences, International Center for Biomedicine (ICC) and University of Chile, Millennium Building, Las Encinas 3370, Ñuñoa, 780023 Santiago, Chile.

International Journal of Alzheimer'S Disease
|April 7, 2012
PubMed
Summary
This summary is machine-generated.

Shilajit, a Himalayan substance, shows potential for cognitive health and Alzheimer's disease treatment. Its active component, fulvic acid, inhibits tau protein aggregation, suggesting therapeutic benefits.

Related Experiment Videos

Last Updated: May 23, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Area of Science:

  • Neuroscience
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Shilajit is a natural substance from the Himalayas, formed from decomposed plants.
  • It is recognized as a safe dietary supplement with potential health benefits.
  • Emerging research suggests Shilajit's role in managing age-related cognitive disorders.

Purpose of the Study:

  • To explore Shilajit's potential in cognitive stimulation and the treatment of cognitive disorders.
  • To investigate the mechanism of action of fulvic acid, Shilajit's active component.
  • To evaluate Shilajit as a nutraceutical for human health and neurological applications.

Main Methods:

  • Review of recent scientific investigations and studies on Shilajit.
  • Analysis of the role of fulvic acid in blocking tau protein self-aggregation.
  • Consideration of Shilajit's molecular and cellular mechanisms.

Main Results:

  • Fulvic acid, a key component of Shilajit, has been shown to inhibit tau self-aggregation.
  • This action presents a potential therapeutic avenue for Alzheimer's disease.
  • Shilajit demonstrates benefits for human health and energetic balance.

Conclusions:

  • Shilajit is a promising nutraceutical with demonstrated health benefits.
  • Its active compounds, particularly fulvic acid, offer potential for neurological therapies.
  • Further basic research and clinical trials are needed to fully understand Shilajit's effects.