Related Experiment Video
Updated: May 23, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
Published on: November 5, 2019
An overview of the effects of sickle cell disease in adolescents
Luhanga Musumadi1, Neil Westerdale, Helen Appleby
1Department of Clinical Haematology, Guy's and St Thomas' NHS Foundation Trust, London. luhanga.musumadi@gstt.nhs.uk
Abstract:
Specific complications of sickle cell disease (SCD) may emerge during adolescence, and education of patients and families is vital during transition from paediatric to adult health care. Adolescents with SCD have to adjust to the constraints of living with a lifelong chronic condition, and compliance with self-care and medical treatments can be problematic. This article explores potential opportunities for intervention, and examines how the role of the adolescent clinical nurse specialist is pivotal in supporting patients and families during this transition.
Related Concept Videos
Multiple Allele Traits
Overview of Hematopoiesis
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Regulation of Hematopoietic Stem Cells
The Functions of the Skeletal System
