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A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms
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Published on: December 19, 2025

Leptospirosis: an institutional experience.

Saumik Datta1, R N Sarkar, Anirban Biswas

  • 1Department of Medicine, Medical College, Kolkata 700073.

Journal of the Indian Medical Association
|April 10, 2012
PubMed
Summary

Leptospirosis, a zoonotic disease, presents variably. Early diagnosis and empirical antibiotics are crucial for managing mild cases and reducing severe complications, despite a declining severe case fatality rate.

Area of Science:

  • Infectious Diseases
  • Zoonotic Diseases
  • Clinical Medicine

Background:

  • Leptospirosis is a significant zoonotic disease with diverse clinical presentations.
  • Early exclusion is vital in febrile patients with hepatorenal dysfunction.
  • Varied prevalence, presentation, and fatality rates are reported across India.

Purpose of the Study:

  • To investigate the presentation, biochemical profile, and complications of leptospirosis.
  • To compare findings with other Indian regions.
  • To assess trends in disease severity.

Main Methods:

  • Fifty-one leptospirosis cases were analyzed.
  • Clinical examinations and laboratory tests including ELISA, hemogram, liver/renal function tests, coagulation profile, CPK, chest X-ray, and ECG were performed.

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  • Data on presenting features and complications were collected.

    • Main Results:

    • Common symptoms included fever (100%), myalgia (78.4%), and headache (41.2%).
    • Key findings were icterus (74.5%), hepatosplenomegaly (72.5%), and bleeding manifestations (35.3%).
    • The case fatality rate was 7.8%, with an observed increase in mild leptospirosis cases.

    Conclusions:

    • Severe leptospirosis has declined, possibly due to increased awareness, diagnostics, and antibiotic use.
    • A high index of suspicion and empirical antibiotic treatment are recommended for suspected cases.
    • Prompt management can reduce leptospirosis complications.