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Related Experiment Video

Updated: May 23, 2026

Iris Fixation via External Pentagram Suturing
05:22

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Intra-operative floppy iris syndrome.

Sandeep Gupta1, Arpana Sharma, Nirupama Bansal

  • 1Department of Surgery, Nepalgunj Medical College and Teaching Hospital, Kohalpur 254839.

Journal of the Indian Medical Association
|April 10, 2012
PubMed
Summary
This summary is machine-generated.

Intra-operative floppy iris syndrome (IFIS), a complication of cataract surgery in patients taking tamsulosin, can be managed. Preoperative atropine or intra-operative visco-adaptive devices may reduce IFIS risks.

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Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Intra-operative floppy iris syndrome (IFIS) is a recently identified complication during cataract surgery.
  • It is associated with the use of tamsulosin, an alpha 1a-adrenergic antagonist prescribed for benign prostatic enlargement.
  • Reported incidences of IFIS range up to 90%, often presenting with severe manifestations.

Purpose of the Study:

  • To review the phenomenon of IFIS.
  • To discuss the efficacy of preoperative tamsulosin withdrawal.
  • To explore methods for mitigating the risks associated with IFIS.

Main Methods:

  • Literature review of studies on IFIS and tamsulosin.
  • Analysis of reported incidence and severity of IFIS.
  • Evaluation of preventative strategies for IFIS.

Main Results:

  • Preoperative withdrawal of tamsulosin has yielded inconsistent results in preventing IFIS.
  • High incidence and severity of IFIS have been documented in affected patients.
  • Strategies like preoperative atropine and intra-operative visco-adaptive devices show potential in reducing IFIS complications.

Conclusions:

  • IFIS poses significant risks during cataract surgery for patients on tamsulosin.
  • Standard preoperative tamsulosin withdrawal may not be consistently effective.
  • Utilizing preoperative atropine or intra-operative visco-adaptive devices are promising approaches to decrease the dangers of IFIS.